FINSysB
Pathogenomics and systems biology of fungal infections - an integrative approach

FINSysB Publications

FINSysB Publications

  1. van de Veerdonk, F. L., Marijnissen, R. J., Kullberg, B. J., Koenen, H. J., Cheng, S. C., Joosten, I., van den Berg, W. B., Williams, D. L., van der Meer, J. W., Joosten, L. A. & Netea, M. G.  2009.  The macrophage mannose receptor induces IL-17 in response to Candida albicans.  Cell Host Microbe, 5(4), 329-340.
  2. Klis, F. M., Brul, S. & De Groot, P. W. 2009.  Covalently linked wall proteins in ascomycetous fungi. Yeast, 27(8), 489-493.
  3. Almeida, R. S, Wilson, D. & Hube B.  2009.  Candida albicans iron acquisition within the host.  FEMS Yeast Research, 9(7), 1000-1012.
  4. Pericolini E., Gabrielli E., Cenci E., De Jesus M., Bistoni F., Casadevall, A. & Vecchiarelli, A.  2009.  Involvement of glycoreceptors in galactoxylomannan-induced T cell death.  J Immunol, 182, 6003-10.
  5. Fringuelli R., Giacchè N., Milanese L., Cenci E., Macchiarulo A., Vecchiarelli A., Costantino G. & Schiaffella, F.  2009.  Bulky 1,4-benzoxazine derivatives with antifungal activity.  Bioorg Med Chem, 17, 3838-46.
  6. Monari C., Bevilacqua S., Piccioni M., Pericolini E., Perito S., Calvitti M., Bistoni F., Kozel T. R. & Vecchiarelli, A.  2009.  A microbial polysaccharide reduces the severità of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production.  J Immunology, 183, 191-200.
  7. Gabrielli E., Pericolini E., Cenci E., Ortelli F., Magliani W., Ciociola T., Bistoni F., Conti S., Vecchiarelli A. & Polonelli, L.  2009.  Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity.  PLoS One, 4, e8187.
  8. Ernst, J. F., & Tielker, D.  2009.  Responses to hypoxia in fungal pathogens.  Cell. Microbiol., 11, 183-190.
  9. Stichternoth, C., & Ernst, J. F.  2009.  Hypoxic adaptation by Efg1 regulates biofilm formation of Candida albicans.  Appl. Environ. Microbiol, 75, 3663-3672.
  10. Tielker, D., Eichhof, I., Jaeger, K.-E., & Ernst, J. F.  2009.  FMN-based fluorescent protein as an oxygen-independent reporter in Candida albicans and Saccharomyces cerevisiae.  Eukaryotic Cell , 8, 913-915.
  11. Willger, S. D., Ernst, J. F., Alspaugh, J. A., & Lengeler, K. B.  2009.  Characterization of the PMT gene family in Cryptococcus neoformans.  PLoS ONE, 4, e6321.
  12. Román, E., Cottier, F., Ernst, J. F. & Pla, J.  2009.  The signaling mucin Msb2 controls the activation of the Cek1 MAP kinase in Candida albicans.  Eukaryotic Cell, 8, 1235-1249.
  13. Moreno, I., Martinez-Esparza, M., Laforet, L. C., Sentandreu, R., Ernst, J. F. & Valentin, E.  2009.  Dosage-dependent roles of the Cwt1 transcription factor for cell wall architecture, morphogenesis, drug sensitivity and virulence in Candida albicans.  Yeast, 27, 77-87.
  14. Ene, I. V. & Bennett, R. J.  2009.  Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans.  Eukaryot Cell., 8(12), 1909-13.
  15. Rosentul, D., Delsing, C., Joosten, L.A.B., van der Meer, J.W.M., Kullberg, B.J. & Netea, M.G.  2009.  Polymorphism in innate immunity genes and susceptibility to recurrent vulvovaginal candidiasis.  Journal of Medical Mycology, 19; 191-196.
  16. Rodaki, A., Enjalbert, B., Bohovych, I.M., Young, T., Odds, F.C., Gow, N.A.R. and Brown, A.J.P.   2009.  Glucose promotes stress resistance in the fungal pathogen, Candida albicans.  Molec. Biol. Cell, 20(22), 4845-4855.
  17. Butler, G, Rasmussen, MD, Lin, MF, Santos, MA, Sakthikumar, S, Munro, CA, Rheinbay, E, Grabherr, M, Forche, A, Reedy, JL, Agrafioti, I, Arnaud, MB, Bates, S, Brown, AJ, Brunke, S, Costanzo, MC, Fitzpatrick, DA, de Groot, PW, Harris, D, Hoyer, LL, Hube, B, Klis, FM, Kodira, C, Lennard, N, Logue, ME, Martin, R, Neiman, AM, Nikolaou, E, Quail, MA, Quinn, J, Santos, MC, Schmitzberger, FF, Sherlock, G, Shah, P, Silverstein, KA, Skrzypek, MS, Soll, D, Staggs, R, Stansfield, I, Stumpf, MP, Sudbery, PE, Srikantha, T, Zeng, Q, Berman, J, Berriman, M, Heitman, J, Gow, NA, Lorenz, MC, Birren, BW, Kellis, M, Cuomo, CA  2009.  Evolution of pathogenicity and sexual reproduction in eight Candida genomes.  Nature, 459(7247); 657-662.
  18. Hube, B.  2009.  Fungal adaptation to the host environment.  Current Opinion in Microbiology, 12(4); 347-349.
  19. Wilson, D, Thewes, S, Zakikhany, K, Fradin, C, Albrecht, A, Almeida, R, Brunke, S, Grosse, K, Martin, R, Mayer, F, Leonhardt, I, Schild, L, Seider, K, Skibbe, M, Slesiona, S, Waechtler, B, Jacobsen, I, Hube, B.   2009.  Identifying infection-associated genes of Candida albicans in the postgenomic era.  FEMS Yeast Research, 9(5); 688-700.
  20. Klis, F. M., Sosinska, G.J., de Groot, P.W., Brul, S.  2009.  Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence.  FEMS Yeast Research, 9(7), 1013-28.
  21. Brown, A. J. P., Haynes, K. & and Quinn, J.  2009.  Nitrosative and oxidative stress responses in fungal pathogenicity.  Current Opinion in Microbiology, 12; 384-391.
  22. d'Enfert, C.  2009.  Hidden killers: persistence of opportunistic fungal pathogens in the human host.  Current Opinion in Microbiology, 12; 358-364.
  23. Nicholls, S., Leach, M. D., Priest, C. L. & Brown, A. J. P.  2009.  Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals.  Molecular Microbiology, 74(4), 844-861.
  24. Skrzypek, F., Cenci, E., Pietrella, D., Rachini, A., Bistoni, F. & Vecchiarelli, A.  2009.  Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation.  Microbes and Infection, 11; 661-670.
  25. Vecchiarelli, A., Pericolini, E.,  Gabrielli, E., Agostini, M., Bistoni, F., Nocentini, G., Cenci, E. & Riccardi, C.  2009.  The GITRL–GITR system alters TLR-4 expression on DC during fungal infection.  Cellular Immunology, 257; 13-22.
  26. Enjalbert, B., Rachini, A., Vediyappan, G., Pietrella, D., Spaccapelo, R., Vecchiarelli, A., Brown, A.J. & d'Enfert, C.  2009.  A multifunctional, synthetic Gaussia princeps luciferase reporter for live imaging of Candida albicans infections.  Infection and Immunonology, 77(11), 4847-4858.
  27. Sorgo, A. G., Heilmann, C. J., Dekker, H. L., Brul, S., de Koster, C. G. & Klis, F. M. 2010. Mass spectrometric analysis of the secretome of Candida albicans.  Yeast, 27(8), 661-672.
  28. Cheng, S. C., Chai, L. Y., Joosten, L. A., Vecchiarelli, A., Hube, B., Van Der Meer, J. W., Kullberg, B. J. & Netea, M. G.  2010. Candida albicans releases soluble factors that potentiate cytokine production by human cells through a protease-activated receptor 1- and 2-independent pathway.  Infection and Immunity, 78(1), 393-399.
  29. Cheng SC, van de Veerdonk F, Smeekens S, Joosten LA, van der Meer JW, Kullberg BJ, Netea MG  2010 Candida albicans dampens host defense by downregulating IL-17 production. Journal of Immunology 185(4), 2450-7
  30. Chai. L, Y., van de Veerdonk, F., Marijnissen, R.J., Cheng, S. C., Khoo, A. L., Hectors, M., Lagrou, K., Vonk, A. G., Maertens, J., Joosten, L. A., Kullberg, B. J. & Netea, M. G.  2010.  Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17) cellular immunity.  Immunology, 130(1), 46-54.
  31. Seider, K., Heyken, A., Luettich, A., Miramón, P. & Hube, B.   2010.  Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape .  Current Opinion in Microbiology, 13, 1-9.
  32. d’Enfert, C., Vecchiarelli, A. & Brown, A. J. P. B.  2010.  Bioluminescent fungi for real-time monitoring of fungal infections.  Virulence, 1(3), 174-176.
  33. Backhaus, K., Heilmann, C. J., Sorgo, A. G., Purschke, G., de Koster, C. G., Klis, F. M. & Heinisch, J. J.  2010.  A systematic study of the cell wall composition of Kluyveromyces lactis.  Yeast, PubMed PMID: 2064102.
  34. Pietrella D., Rachini A., Torosantucci, A., Chiani, P., Brown, A. J., Bistoni, F., Costantino, P., Mosci, P., d’Enfert, C., Rappuoli, R., Cassone, A. & Vecchiarelli, A.  2010.  A beta-glucan-conjugate vaccine and anti-beta-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique.  Vaccine, 28, 1717-25.
  35. Hornbach, A., Heyken, A., Schild, L., Hube, B., Löffler, J. & Kurzai, O.  2010.  The glycosylphosphatidylinositol-anchored protease Sap9 modulates the interaction of Candida albicans with human neutrophils.  Infection and Immunity, 77(12), 5216-5224.
  36. Dalle, F., Wächtler, B., L'Ollivier, C., Holland, G., Bannert, N., Wilson, D., Labruère, C., Bonnin, A. & Hube, B.  2010.  Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes.  Cell Microbiology, 12(2), 248-271.
  37. Gropp, K., Schild, L., Schindler, S., Hube, B., Zipfel, P. F. & Skerka, C.  2010.  The yeast Candida albicans evades human complement attack by secretion of aspartic proteases.  Molecular Immunology,  47(2-3), 465-475.
  38. Wilson, D. & Hube, B.  2010.  Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation.  Eukaryotic Cell, 9(2), 278-287.
  39. Vecchiarelli A. & Monari C.  2010.  Microbial polysaccharide: new insights for treating autoimmune diseases.  Front Biosci (Schol Ed), 2         256-67.
  40. Spiering, M. J.,  Moran, G. P., Chauvel, M., MacCallum, D. M., Higgins, J., Hokamp, K., Yeomans, T., d’Enfert, C., Coleman, D. C. & Sullivan, D. J.  2010.  Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted Epithelial Infection Model          .  Eukaryotic Cell, 9(2), 251-265.
  41. Spiesser, T. W., Diener, C., Barberis, M. & Klipp, E.  2010.  What influences DNA replication rate in budding yeast?  PLoS One, 5(4), e:10203.
  42. Zi, Z., Liebermeister, W. & Klipp, E.  2010.  A quantitative study of the Hog1 MAPK response to fluctuating osmotic stress in Saccharomyces cerevisiae.  PLoS One, 5(3), e:9522.
  43. Kühn, C., Prasad, K. V., Klipp, E. & Gennemark, P.  2010.  Formal representation of the high osmolarity glycerol pathway in yeast.  Genome Inform., 22, 69-83.
  44. Gerber, S., Hasenbrink, G., Hendriksen, W., Van Heusden, P., Ludwig, J., Klipp, E. & Lichtenberg-Fraté H.  2010.  Graphical analysis and experimental evaluation of Saccharomyces cerevisiae PTRK1|2 and PBMH1|2 promoter region.  Genome Inform., 22, 11-20.
  45. Pietrella D,  Angiolella  L, Rachini A, Mondello F, Bistoni F , Palamara AT  Vecchiarelli (2010) A. Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection. BMC Complementary and Alternative Medicine 11, 18
  46. Brown AJP, Leach MD, Nicholls S. The relevance of heat shock regulation in fungal pathogens of humans. (2010) Virulence 1(4) 330-332
  47. Leach MD, Tyc KM, Shapiro RS, Cowen LE, Klipp E, Brown AJP (2011) Modelling the regulation of thermal adaptation by Hsf1 and Hsp90 in Candida albicans, a major fungal pathogen of humans. Submitted
  48. Tyc KM, Klipp E (2011) Modeling dissemination of pathogenic fungi within a host: a cartoon for the interactions of two complex systems. In press
  49. Frank L. van de Veerdonk, Theo S. Plantinga, Alexander Hoischen, Sanne P. Smeekens, Leo A.B. Joosten, Christian Gilissen, Peer Arts, Diana C. Rosentul, Andrew J. Carmichael, Chantal A.A. Smits-van der Graaf, Bart Jan Kullberg, Jos W.M. van der Meer, Desa Lilic, Joris A. Veltman, and Mihai G. Netea. (2011) STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis. New England Journal of Medicine 365, 54-61
  50. Rosentul DC, Plantinga TS, Oosting M, Scott WK, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Laird GM, Joosten LA, van der Meer JW, Perfect JR, Kullberg BJ, Netea MG, Johnson MD. (2011) Genetic Variation in the Dectin-1/CARD9 Recognition Pathway and Susceptibility to Candidemia. Journal of Infectious Diseases Oct;204(7), 1138-1145
  51. Rosentul DC, Plantinga TS, Scott WK, Alexander BD, van de Geer NM, Perfect JR, Kullberg BJ, Johnson MD, Netea MG. (2011) The impact of caspase-12 on susceptibility to candidemia. Eur J Clin Microbiol Infect Dis. ePub
  52. Diana C Rosentul, Theo S Plantinga, Antonios Papadopoulos, Leo AB Joosten, Anastasia Antoniadou, Hanka Venselaar, Bart-Jan Kullberg, Jos WM van der Meer, Evangelos J Giamarellos-Bourboulis, Mihai G Netea (2011) Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients. Immunological Investigations. Accepted
  53. Cheng SC, van de Veerdonk FL, Lenardon M, Stoffels M, Plantinga T, Smeekens S, Rizzetto L, Mukaremera L, Preechasuth K, Cavalieri D, Kanneganti TD, van der Meer JW, Kullberg BJ, Joosten LA, Gow NA, Netea MG  (2011) The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. J Leukoc Biol 90(2) 357-366
  54. Heilmann CJ, Sorgo AG, Siliakus AR, Dekker HL, Brul S, de Koster CG, de Koning LJ, Klis FM. (2011) Hyphal Induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile. Microbiology 157, 2493-2503.
  55. Sorgo AG, Heilmann CJ, Dekker HL, Brul S, de Koster CG, de Koning LJ, Klis FM. (2011) The effects of fluconazole on the secretome, the wall proteome and wall integrity of the clinical fungus Candida albicans. Eukaryot Cell 10, 1071-1081.
  56. Sosinska GJ, de Koning LJ, de Groot PW, Manders EM, Dekker HL, Hellingwerf KJ, de Koster CG, Klis FM. (2011) Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH. Microbiology 157, 136-146.
  57. Klis FM, de Koster CG, Brul S (2011) A mass spectrometric view of the fungal wall proteome. Future Microbiology 6, 941-951.
  58. Buerth C, Heilmann CJ, Klis FM, de Koster CG, Ernst JF, Tielker D. (2011) Growth-dependent secretome of Candida utilis. Microbiology 157 in press
  59. Shih-Chin Cheng, Tom Sprong, Leo A.B. Joosten, Jos W.M. van der Meer,  Bart-Jan Kullberg, Bernhard Hube, Lone Schejbel, Peter Garred Marcel van Deuren, Mihai G. Netea (2011) A central role of complement for the Candida albicans-induced cytokine production by human cells. Submitted.
  60. Pietrella, D., Enjalbert, B., Zeidler, U., Znaidi, S., Rachini, A., Vecchiarelli, A., d’Enfert, C. (2011) A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections. Methods Mol Biol, in press
  61. Cabral, V., Chauvel, M., Firon, A., Legrand, M., Nesseir, A., Bachellier-Bassi, S., Chaudhari, Y., Munro, C. & d’Enfert, C. (2011)  Modular gene over-expression strategies for Candida albicans. Methods Mol Biol, in press
  62. Riera, M., Moreno-Ruiz, E., Goyard, S., d’Enfert, C. & Janbon, G. Biofilm formation studies in microtiter format. (2011) Methods Mol Biol, in press
  63. Bonhomme, J., Chauvel, M., Goyard, S., Roux, P., Rossignol, T., d'Enfert, C. (2011) Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans Mol. Microbiol. 80, 995-1013.
  64. Legrand, M., Munro, C. and d'Enfert, C. (2011) Cool Tools 5: The Candida albicans ORFeome Project. Candida and candidiasis, 2nd Edition; Calderone and Clancy, eds; ASM Press, in press.
  65. Chauvel, M., Nesseir, A., Goyard, S., Bachellier-Bassi, S., Firon, A., Diogo, D., Naulleau, C., Rossignol, T. and d'Enfert, C. (2011)  An over-expression screens unravels novel links in the regulation of morphogenesis in Candida albicans. Submitted.
  66. Pietrella D, Rachini A, Pandey N, Schild L, Netea M, Bistoni F, Hube B, Vecchiarelli. A. (2011) Inflammatory response induced by aspartic proteases of C. albicans is independent from proteolytic activity. Infect Immun. 78, 4754-4762.
  67. Linde J, Wilson D, Hube B, Guthke R. (2011) Regulatory network modelling of iron acquisition by a fungal pathogen in contact with epithelial cells. BMC Syst Biol 4, 148
  68. Seider K, Brunke S, Schild L, Jablonowski N, Wilson D, Majer O, Barz D, Haas A, Kuchler K, Schaller M, Hube B. (2011) The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation. J IMMUN, accepted
  69. Wächtler B, Wilson D, Hube B. (2011) Candida albicans adhesion, invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole. Antimicrob Agents Chemother. Accepted
  70. Losse J, Svobodová E, Heyken A, Hube B, Zipfel PF, Józsi M. (2011) Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human  neutrophils. Mol Immunol accepted
  71. Schild L, Heyken A, de Groot PWJ, Hiller E, Mock M, de Koster C, Horn U, Rupp S, Hube B. (2011) Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10. Eukaryt Cell 10, 98-109.
  72. Wächtler B, Wilson D, Haedicke K, Dalle F, Hube B (2011) From attachment to damage: Defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells. PLoS One 6, e17046
  73. Luo SS, Blom AM, Rupp S, Hube B, Hipler UC, Skerka C, Zipfel PF. (2011) The ph-regulated antigen 1 of Candida albicans interacts with C4b-binding protein (C4BP) and mediates fungal contact with human enothelial cells. J Biol Chem 286, 8021-8029.
  74. Martin R, Moran GP, Jacobsen ID, Heyken A, Domey J, Sullivan DJ, Kurzai O, Hube B. (2011) The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension. PLoS One 6, e18394
  75. Jacobsen ID, Große K, Berndt A, Hube B. (2011) Pathogenesis of Candida albicans infections in the alternative chorio-allantoic membrane chicken embryo model resembles systemic murine infections. PLoS One 6, e19741
  76. Martin R, Wächtler B, Schaller M, Wilson D, Hube B. (2011) Host-pathogen interactions and virulence associated genes during Candida albicans oral infections. Int J Med Microbiol, 301, 417-422
  77. Boisramé, A., Cornu, A., Da Costa, G., Richard, M.L. (2011) An unexpected role for a serine/threonine-rich domain in the Candida albicans Iff protein family. Eukaryotic Cell in press
  78. Eva Pericolini, Elena Gabrielli, Elio Cenci, Stefano Perito, Jacky Chow, Francesco Rosario Donato, Francesca Riuzzi, Francesco Bistoni, Arturo Casadevall, Anna Vecchiarelli. (2011) Role of CD45 signaling pathway in Galactoxylomannan-induced T cell death. PLoS One 5(9), e12720
  79. Miranda Piccioni, Claudia Monari, Sara Bevilacqua, Stefano Perito, Francesco Bistoni, Thomas R Kozel, Anna Vecchiarelli. (2011) A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide. Clinical and Experimental Immunology 165(2) 190-201
  80. Pietrella D, Rachini A,Pines M,Pandey N, Mosci P,d'Enfert C,Vecchiarelli A. (2011) Th17 cells and Il-17 in Protective Immunity to Vaginal Candidiasis. PLoS One 6(7) e22770
  81. Vecchiarelli A, Pericolini E, Gabrielli E, Chow SK, Bistoni F, Cenci E, Casadevall A. (2011) Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy. Immunotherapy 3(8) 997-1005
  82. Stichternot C., Fraund A, Setiadi E, Giasson L, Vecchiarelli A, Ernst, J. F. (2011) Sch9 kinase integrates hypoxia and CO2 sensing to suppress hyphal morphogenesis in Candida Albicans. Eukaryot Cell 10(4) 502-511
  83. Lassak, T., Schneider, E., Bussmann, M., Kurtz, D., Manak, J. R., Srikantha, T., Soll, D. R., and Ernst, J. F. (2011)Target specificity of the Candida albicans Efg1 regulator. Molecular Microbiology in press
  84. Brown, A.J.P., Haynes, K., Gow, N.A.R. and Quinn, J. (2011) Stress responses in Candida. In Candida and Candidiasis (Clancy, C.J. & Calderone, R.A, eds.) ASM Press (in press).
  85. You, T., Coghill, G.M. and Brown, A.J.P. (2011) Eukaryotic translation initiation factor interactions. In “Encyclopedia of Systems Biology” (Dubitzky, W., Wolkenhauer, O., Cho, K.H. &  Yokota, H., eds.) Springer, Heidelberg, Germany, (in press).
  86. You, T., Coghill, G.M. and Brown, A.J.P. (2011) Translational control of GCN4. In “Encyclopedia of Systems Biology” (Dubitzky, W., Wolkenhauer, O.,  Cho, K.H. &  Yokota, H., eds.) Springer, Heidelberg, Germany, 5:131 doi:10.1186/1752-0509-5-131.
  87. Leach, M.D., Stead, D.A., Argo, E. and Brown, A.J.P. (2011) Sumoylation affects growth, morphology and stress resistance in the pathogen, Candida albicans. Molec. Biol. Cell. 22, 687-702.
  88. Nicholls, S., MacCallum, D.M., Kaffarnik, F.A.R., Selway, L., Peck, S.C. and Brown, A.J.P. (2011) Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans.  Fungal Genet. Biol. 48, 297-305.
  89. Leach, M.D., Stead, D.A., Argo, E., MacCallum, D.M. and Brown, A.J.P. (2011) Proteomic and molecular analyses highlight the importance of ubiquitination for stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans. Molec. Microbiol. 79, 1574-1593

FINSysB Conference Presentations

Invited Presentations

  1. d’Enfert, C.  Member of the scientific committee and organizing committee of the 27th International Symposium on Yeasts. Pasteur’s legacy: Yeasts for health and biotechnologies. Paris, France, 26-29 August, 2009
  2. d’Enfert, C.  Candida albicans, une levure particulière.  Scientific Council Conference, Institut Pasteur, Paris, France, October 29, 2009,
  3. Hube B.  Session chair; Host-Fungus Interaction.  Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  La Colle-Sur-Loup, France, 2 – 8 May, 2009.        
  4. Hube B.  Plenary talk; Candida albicans - from commensal to life-threatening pathogen.  Congress on Sepsis.         Weimar, Germany, 9 – 12 September, 2009.
  5. Hube B.  Iron acquisition of Candida albicans during oral infections.  17th Congress of the ISHAM. Tokyo, Japan, 24 – 29 May, 2009
  6. Hube B.  Use of in vitro models to study the Candida albicans infection process.  17th Congress of the ISHAM.  Tokyo, Japan, 24 – 29 May, 2009.
  7. Hube B.  Fungal virulence schools and immune evasion strategies.  VAAM Pilz-Tagung.  Münster, Germany, 27 – 30 September, 2009.
  8. Hube B.  Plenary talk; From commensal to pathogen: molecular dissection of Candida albicans oral infections.  FEBS Advanced practical and lecture course.  Madrid, Spain, 1 – 14 Feb, 2009.
  9. Klis, F. M.  Inaugural lecture; Covalently linked cell wall proteins. IV International Conference on “Molecular Mechanisms in Fungal Cell Wall Biogenesis”. Warsaw, Poland, 30 August – 3 September, 2009.
  10. Moreno-Ruiz, M., Galán-Díez, M., Edgerton, W., Zhu, E., Fernandez-Ruiz, P., Cossart and d'Enfert, C.  Mechanisms of invasion of host cells by Candida albicans.  Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  May 2-8, 2009.  La Colle-Sur-Loup, France.
  11. d'Enfert, C.  Mécanismes moléculaires impliqués dans la formation de biofilms par Candida albicans et dans leur résistance aux antifongiques.  Congrès de la Société Française de Parasitologie et de la Société Française de Mycologie Médicale.  June 17-19, 2009.  Poitiers, France.
  12. d'Enfert, C.  Role of the clathrin-dependent endocytic machinery in the internalization of Candida albicans by epithelial and endothelial cells.  AFG Reading Party.  January 14, 2009.  University of Aberdeen, UK.
  13. d'Enfert, C., Filler, S., Veiga, E., Solis, N., Phan, Q.,  Sun, J. & Nayyar, N.  Candida albicans cell wall proteins: host-pathogen interactions, cell wall biogenesis and maintenance.  January 16, 2009.  INRA, Versailles, France.
  14. d'Enfert, C.  Member of the scientific and organizing committee and session chair; 27th International Specialized Symposium on Yeasts, August 26-29, 2009.  Paris, France.
  15. d'Enfert.  Chair; Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  May 2-8, 2009.  La Colle-Sur-Loup, France.
  16. Klipp, E.  Modeling of Cellular Stress Response.  BioValley – Science Day, 13 October, 2009, Basel.
  17. Ernst, J. F.  Mannoproteins and cell surface signaling in Candida albicans.  IV International Conference on Molecular Mechanisms in Fungal Cell Wall Biogenesis. Warsaw, Poland, August/September 2009.
  18. Stichternoth, C. & Ernst, J. F.  Regulation der Candida albicans Biofilmbildung durch Hypoxie und Kohlendioxid. 43. Wissenschaftl. Tagung der DMYK, Köln, Cologne, Germany, 3-5 September, 2009.
  19. Vecchiarelli, A.  La Capsula di Cryptococcus neoformans. Effetti immunosoppressivi ed antinfiammatori: due facce della stessa medaglia.  Congresso Nazionale della Società Italiana di Microbiologia.  Torino, Italy, 11-14October, 2009.
  20. Bohovych, I.M. & Brown, A.J.P.  Glucose enhances oxidative stress resistance in Candida albicans via specific signalling pathways.  IMC9: The Biology of Fungi, Edinburgh, UK, 1 -6 August, 2010.
  21. Bohovych I., & Rodaki A.  Glucose promotes stress resistance in Candida albicans.  Scientific Seminar for students, Ivano-Frankivsk, Ukraine,4 January, 2010.
  22. Klipp, E.  Mathematical modeling of cellular stress response in yeast and the integration of different signals.  IMC9 The Biology of Fungi , 1-6 Aug 2010, Edinburg, UK.
  23. Klipp, E.  Computational modeling of yeast cell stress response.  BIMBS Mitte Open Day, 2 July, 2010, Berlin.
  24. Klipp, E.  Mathematical modeling of cellular stress response.  MPI Infectious Biology, 5 May, 2010, Berlin.
  25. Klipp, E.  Integration of Different Signals in Cellular Stress Response.  Systems Biochemistry- Linked Focused Meeting, 22-24 March, 2010, University of York, UK.
  26. Klipp, E.  Integration of Different Signals in Cellular Stress Response.  Systems Biology of Microorganisms, 22-24 March, 2010, Institut Pasteur, Paris, France.
  27. Vecchiarelli, A..  Cross-talk between innate and adaptive immunity to fungal pathogens.  8th world congress on Trauma, Shock, Inflammation and Sepsis, Munich, Germany, 9-13 March 2010.
  28. Ernst JF  Regulation of protein-O-mannosylation in Candida albicans. 28th Small Meeting on Yeast Transport and Energetics. Delhi, India, 23-27 October 2010
  29. Ernst JF.  Signaling the glycoshield in Candida albicans.  Seminar University JNCS, JNCASR, Bangalore, India, 28 October 2010
  30. Hube B.  Using transcript profiling to decipher interactions of Candida albicans with the host.  3rd Research Skills Training Workshop 'MICROARRAY ANALYSIS, NEXT GENERATION SEQUENCING AND BIOINFORMATICS'.  Institut Pasteur, Paris, France, 20 - 23 April, 2010.
  31. Wächtler, B., Wilson, D., Dalle, F., Schaller, M. & Hube, B.  From attachment to damage: Candida albicans set of genes contribute to distinct stages of interactions with oral epithelial cells.  10th ASM Conference on Candida and Candidiasis.  Miami, Florida, 22 – 26 March, 2010.
  32. Mayer, F., Wilson, D., Jacobsen, I. & Hube, B.  Candida albicans BIS1 mediates stress adaptation and virulence.  DGHM – VAAM.  Hannover, Germany, 28 - 31March, 2010.
  33. Schild, L., Heyken, A., de Groot, P., Hiller, E., Rupp, S. & Hube , B.  Candida albicans GPI-anchored proteases modulate fungal cell wall functions and interaction with host cells.  DGHM – VAAM.  Hannover, Germany, 28 – 31 March, 2010.
  34. Hube B.  Dissection of the invasion process of Candida albicans.  Meeting of Paul Ehrlich Society.  8 – 9 March, 2010.
  35. Hube B.  Fungal virulence schools and immune evasion strategies.  Aberdeen Fungal Group Reading Party.  Edzell, Scotland, 11 – 15 January, 2010.
  36. Klis, F. M.  Interview (used for high school students)  http://www.science.uva.nl/sils/home.cfm/50B68677-1321-B0BE-A4235CB16115EFBB.
  37. d’Enfert, C.  Molecular mechanisms involved in the formation of Candida albicans biofilms and their resistance to antifungals. Colloque Biofilm et Santé, Poitiers, 11-12January, 2010.
  38. d’Enfert, C.  Candida albicans in the genomic era: population genomics, biofilms and morphogenesis. Hôpital Bichat, Paris, France, 18 February, 2010.
  39. Hube B. Principles of fungal virulence: attachment, invasion, damage and immune evasion. 2nd Central European Summer Course on Mycology: Biology of pathogenic fungi. Szeged, Hungary, July 5-9, 2010
  40. Hube B  Identification and characterisation of virulence associated genes during oral infections with Candida albicans.  Annual Meeting of the DFG Priority Programme SPP 1160. Bad Staffelstein, Germany. November 29-December 1, 2010
  41. G.Morace, Vecchiarelli A. Fattori di virulenza e strategie di controllo degli opportunisti fungini. 38th Italian Microbiology Society Congress. Riccione , Italy, October 17-20, 2010
  42. Hube B. From commensal to pathogen: Stage- and tissue specific gene expression of Candida albicans. Consilium Mycologicum, 8th Workshop, Berlin, Germany, April 16-17, 2010
  43. Nesseir,  Bachellier-Bassi, S., Chaudhari, Y.,  Chauvel, M., Cabral,V., Diogo, D., Firon, A., Goyard, S., Lee, K., Legrand, M., Mohandas, D., Rajan, L., Rossignol, T., Zeidler, U.,. Znaidi, S., d’Enfert, C. & Munro, C. The Candida albicans ORFeome project. 10th ASM Candida and candiasis.  Miami, USA,  22-26 March, 2010.
  44. d’Enfert, C.  Candida albicans in the genomic era: population genomics, biofilms and morphogenesis. Szeged University, Hungary, February, 2010.
  45. d’Enfert, C.  Regulation of morphogenesis in Candida albicans. 7th National Congress of the French Society for Microbiology.  Paris, France., 2-4June, 2010.
  46. Znaidi, S., Cabral, V., Legrand, M., Firon, A., Chauvel, M. & d’Enfert, C. A parallel conditional gene-overexpression screen identifies regulators of Candida albicans fitness. Levures, Modèles et Outils IX, Strasbourg, August 30- September 2, 2010.
  47. Brown AJP. Microbial interactions with humans: Candida albicans, a fungal case study. MiCom 2010, Jena, Germany
  48. d’Enfert C. Candida biofilms and adaptation to hypoxia. Biofilms in nosocomial infections. Paris, France, January 31 - February 1, 2011
  49. d’Enfert C. Fungal infections in the genomic era. Meeting of the Korean Society for Laboratory Medicine. Daejon (Korea) June 10, 2011
  50. d’Enfert C. Candida biofilms and adpatation to hypoxia. Inaugural meeting of the Irish Fungal Society. Dublin, Ireland June 16-17, 2011
  51. d’Enfert C. The inside and outside of Candida albicans biofilms. 2nd Student Conference on Microbial Communication. Jena, Germany, September 13-16 2011
  52. Lassak, T. and Ernst, J. F.  Target specificity of the Efg1 regulator  in Candida albicans. Tagung d. DGHM Fachgruppe Eukaryontische Krankheitserreger. Düsseldorf, Germany, 25-26 March 2011
  53. Hube B. Yeast vs. hyphae: Roles in Candida virulence. Annual Meeting of the British Mycological Society. Glasgow, UK, April 17-19, 2011
  54. Hube B. Interactions of Candida albicans with oral epithelial cells. Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011
  55. Hube B. Fungal virulence schools and immune evasion strategies.  Molecular Biology Department Umeå University, Sweden. May 27, 2011
  56. Lüttich A, Brunke S, Jacobsen ID, Hube B.  Microevolution of a nonfilamentous Candida albicans mutant during co-incubation with macrophages. FEBS Human Fungal pathogens Course 2011. La Colle sur Loupe, France, May 2011
  57. Klis F. Lessons to be learned from the wall proteome and secretome of C. albicans for infection detection and vaccine development. Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011
  58. Vecchiarelli A. Capsular Material of Cryptococcus neoformans: virulence and much more. 8th International Conference on Cryptococcus and Cryptococcosis. Charleston, S.Carolina, USA, May 1-5, 2011
  59. Vecchiarelli A C. neoformans capsular polysaccaride and T cell damage. . Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011
  60. d’Enfert C. Biofilms in humans: a multitude of interactions. Interactive workshop 2nd Student Conference on Microbial Communication. Jena, Germany, September 13-16 2011
  61. Brown AJP.  Adapting to change – coordinating adaptive responses in a  major fungal pathogen of humans. Katholieke Universiteit Leuven, Leuven, Belgium, May 2011
  62. Brown AJP. Candida albicans pathogenesis and systems biology. FEBS Human Fungal pathogens Course 2011. La Colle sur Loupe, France, May 2011
  63. Brown AJP.  How does a major fungal pathogen adapt to its human host? University of Goettingen, Goettingen, Germany, June 2011
  64. Brown AJP. Impact of combinatorial stresses upon the fungal pathogen Candida albicans. FEMS Conference, Geneva, Switzerland, June 2011

Other Presentations

  1. d’Enfert, C.  An over-expression approach for the identification of regulators of Candida albicans morphogenesis. INRA Micalis, Jouy-en-Josas, 10 December, 2009.
  2. Sorgo, A.  Changes of the Candida albicans cell wall proteome under medically relevant conditions.  Yeasterday 2009.    June 5, 2009.  Amsterdam, The Netherlands.
  3. Dobb, K.  Prize winning lay summary, The Sex Lives and Deadly Weapons of Killer Fungi.  2009  University of Manchester, UK.
  4. Nesseir, A., Chauvel, M., Diogo, D., Firon, A., Rossignol, T., Goyard, S., Kaffarnik, F.A.R., Selway, L., Peck S. C. & d’Enfert, C.  Understanding the role of the Candida albicans Yak1 kinase in the regulation hyphal growth.  Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  May 2-8, 2009.  La Colle-Sur-Loup, France.
  5. Dobb, K.  Essential Genes as Broad Spectrum Antifungal Targets.  Group meeting, University of Manchester, UK, 8 February, 2010.
  6. Ene, I.V., Brown, AJP. Osmotic responses of C. albicans grown on alternative C sources. CRISP Meeting, Aberdeen UK, May13, 2010
  7. Wilson D, Hube B. Candida albicans adaptation to the host from the perspective of transcriptional profiling. 9th International Mycological Congress (IMC): The Biology of Fungi. Edinburgh, UK, August 1-6, 2010
  8. Hube B. Interactions of Candida albicans with mucosal surface. Interdisciplinary Forum on Superficial Fungal Infections. Jena, Germany, October 11-13, 2010
  9. Heilmann C. Quantitative strategies to map the Candida albicans cell wall proteome. NWO The Analytical Challenge. Lunteren, Netherlands, November 1st-2nd 2010
  10. Heilmann C. Relative quantification of the wall proteome of Candida albicans during the yeast-to-hypha transition. NWO Proteins, nucleic acids and Lipids. Veldhoven, Netherlands, December 6th-7th 2010
  11. Miramón -Martínez, P. Dissecting the response of Candida albicans to neutrophils. 4th FEBS Advanced Lecture Course Human Fungal Pathogen 2011, La Colle sur Loup, France, May 07-13, 2011
  12. Ene, I.V., Neil A. R. Gow, Brown, A.J.P. Impact of non-fermentative growth on the C. albicans cell wall  and dynamic stress responses. BSMM Annual Scientific Meeting. Glasgow, UK, April 17-19, 2011
  13. Polke M, Hube B. DGHM-Statusworkshop FG Eukaryontische Krankheitserreger, Düsselsdorf, Germany, May 25-26, 2011
  14. Wächtler, B., Wilson, D., Dalle, F., Schaller, M. & Hube, B. From attachment to damage: Candida albicans set of genes contribute to distinct stages of interactions with oral epithelial cells. BSMM Annual Scientific Meeting. Glasgow, UK, April 17-19, 2011
  15. Wilson D, Hube B. Candida albicans unique genes: Specific roles in host cell damage. 111th General Meeting of the American Society for Microbiology (ASM). New Orleans, USA, May 21-24, 2011
  16. Heilmann C. Quantitative mass spectrometry reveals new therapeutic targets against the human fungal pathogen Candida albicans. 100th Anniversary Meeting of the NVvM, Papendal, Netherlands, April 18th-20th, 2011
  17. Boisramé A., Cornu A., Da Costa G., Monniot C., Kos I. and Richard M.L. Mini-Symposium Micalis, Jouy-en-Josas (France) February 10, 2011
  18. Bohovych I Glucose promotes oxidative stress resistance in Candida albicans via specific signalling pathways.  International Symposium “Non-Conventional Yeasts in the Postgenomic Era” Lviv, Ukraine, September 11-14 2011
  19. Ene, I.V., Brown, A.J.P. Growth on non-fermentative C sources affects cell wall architecture and hence dynamic responses to osmotic stress in the fungal pathogen C. Albicans. Joint BES / SEB / BS Symposium 2010 Stress Responses – molecules, organisms, environments. London, UK, 4-7 January 2011
  20. Ene, I.V., Neil A. R. Gow, Brown, A.J.P. Impact of non-fermentative growth on the C. albicans cell wall  and dynamic responses to osmotic stress. FEBS Advanced practical and lecture course. La Colle sur Loup, France, May 07-13, 2011
  21. S. Znaidi, V. Cabral, M. Legrand, A. Firon, M. Chauvel and C. d’Enfert. Fitness Profiling in Candida albicans by Systematic Gene Overexpression. . FEBS Advanced practical and lecture course. La Colle sur Loup, France, May 07-13, 2011
  22. Kaloriti D. Jacobsen M, Tillmann A, Patterson M, Haynes K, Quinn J, Gow N, Brown  A. The impact of combinations of osmotic, oxidative and nitrosative stresses upon the pathogenic yeast Candida albicans BSMM  Meeting, April 2011, Glasgow, UK.
  23. Kaloriti D. Jacobsen M, Tillmann A, Patterson M, Haynes K, Quinn J, Gow N, Brown  A. The impact of combinations of Osmotic and Oxidative stresses upon the pathogenic yeast Candida albicans. SGM Conference April 2011, Harrogate, UK
  24. Tillmann A., Kaloriti D., Jacobsen M., Gow N.A.R., Brown A.J.P. The medical importance of nitrosative stress and combinatorial stresses in the human fungal pathogen Candida albicans.  45. Wissenschaftliche Tagung der Deutschsprachigen Mykologischen Gesellschaft, September 2011, Kiel, Germany 
  25. Tillmann A., Gow N. A. R., Brown A. J. P. “NO” signalling pathways in Candida albicans. Conference Biochemistry Society ‘Nitrogen Cycle’ April 2011 Birmingham, UK.
  26. Saxena A.  Immunotherapeutic Targeting of Fungal PAMPs - Analysis of Ovine Antibody Repertoire against Fungal PAMPs on Active Immunization, at Burn Reading Party,12th January, 2011, Burn House, UK

Posters

  1. Sorgo, A. G., Heilmann, C. J., de Koning, L. J., Dekker, H. L., de Koster, C. G., Brul, S. & Klis, F. M.  The effects of Fluconazole on the cell wall proteins and secreted proteins of Candida albicans. IV International Conference on “Molecular Mechanisms in Fungal Cell Wall Biogenesis”. Warsaw, Poland, 30 August – 3 September, 2009.
  2. Miramón, P., Heyken, A., Leonhardt I., Barz, D. and Hube, B.  Characterisation of Candida albicans-neutrophil interaction using mutants and GFP-reporter strains.  Neutrophil granulocytes revisited.   International symposium on novel functions of neutrophil granulocytes.  September 10-12, 2009.  Luebeck, Germany.
  3. Sorgo, A. G., Heilmann, C. J., de Koning, L., Dekker, H. L., de Koster, C., Brul, S. and Klis, F. M.  The effects of Fluconazole on the cell wall proteins and secreted proteins of Candida albicans.  IV International Conference on "Molecular Mechanisms in Fungal Cell Wall Biogenesis".  August 30 - September 3, 2009.  Warsaw, Poland.
  4. Miramón -Martínez, P., Albrecht,A.,  Leonhardt, I, and Hube, B.  How do neutrophils detect, inhibit and kill Candida albicans?  Third FEBS Advanced Lecture Course Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence.  May 2-8, 2009.  La Colle sur Loup, France.
  5. Heilmann, C. J., Sosinska, G., Sorgo, A. G., Nijsse, M., Dekker, H. L., Roseboom, W., Brul, S., de Koster, C., de Koning, L & Klis, F. M.  Mapping of medium proteins and covalently anchored cell wall proteins of Candida albicans grown at neutral and acidic pH.  IV International Conference on “Molecular Mechanisms in Fungal Cell Wall Biogenesis”, Warsaw, Poland, 30 August – 3 September, 2009.
  6. Heilmann, C. J., Sorgo, A. G., Sosinska, G., Nijsse, M., Dekker, H. L., de Koster, C. G., Brul, S., de Koning, L. J. & Klis, F. M.  Quantitative mapping of medium proteins and covalently anchored wall proteins of Candida albicans: neutral vs. acidic pH.  NWO Analytical Chemistry & NVMS Lunteren, The Netherlands, 2 – 3 November, 2009.
  7. Heilmann, C. J., Sorgo, A. G., Sosinska, G., Nijsse, M., Dekker, H. L., de Koster, C. G., Brul, S., de Koning, L. J. & Klis, F. M.  Relative quantification of Candida albicans medium proteins and covalently anchored wall proteins: neutral vs. acidic pH. NWO-CW study groups Protein research, nucleic acids, lipids & biomembranes, Veldhoven, The Netherlands, 7 – 9 December, 2009.
  8. Cantero, P. & Ernst, J. F.  Regulation of the PMT1 gene in Candida albicans.  IV International Conference on Molecular Mechanisms in Fungal Cell Wall Biogenesis. Warsaw, Poland, August/September 2009.
  9. Szafranski,. E., Cottier, F. & Ernst, J. F.  Analysis of Msb2 in Candida albicans.  IV International Conference on Molecular Mechanisms in Fungal Cell Wall Biogenesis. Warsaw, Poland, August/September 2009.
  10. Hilbig, J. & Ernst, J. F.  Dom34 as a regulator of O-glycosylation in C. albicans.  IV International Conference on Molecular Mechanisms in Fungal Cell Wall Biogenesis. Warsaw, Poland, August/September 2009.
  11. Juchimiuk. M., Orlowski. J., Litwicka. P., Ernst. J. & Palmaczyk. G.  Impaired synthesis of dolichol prevents hyphae formation and alters the cell wall fo Candida albicans.  IV International Conference on Molecular Mechanisms in Fungal Cell Wall Biogenesis. Warsaw, Poland, August/September 2009.
  12. Tielker, D., Eichhof, I., Jaeger, K.-E. & Ernst, J. F.  T Anaerobic fluorescent reporter proteins for Candida albicans and Saccharomyces cerevisiae. 27th International Specialized Symposium on Yeasts. Paris, France, 26-2 September 2009.
  13. Lassak, T. & Ernst, J. F.  Molecular mechanisms for negative autoregulation of the EFG1 gene in Candida albicans. 27th Small Meeting on Yeast Transport and Energetics. Blankenberge, Belgium, 4-8 September 2009.
  14. Eichhof., I., Tielker, D., Jaeger., K.-E. & Ernst, J. F.  FMN-based fluorescent protein as an oxygen-independent reporter in Candida albicans and Saccharomyces cerevisiae. 27th Small Meeting on Yeast Transport and Energetics, Blankenberge, Belgium, 4-8 September 2009.
  15. Kurtz, D., Tielker, D. and Ernst, J. F.  Target sequence recognition of the Efg1 regulator in Candida albicans. 27th Small Meeting on Yeast Transport and Energetics, Blankenberge, Belgium, 4-8 September 2009.
  16. Cantero, P. D. & Ernst, J. F.  Regulation of PMT genes encoding protein O-mannosyltransferases in Candida albicans. 3rd FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, 2-8 May 2009.
  17. Stichternoth, C. & Ernst, J. F.  Hypoxic adaptation by Efg1 regulates biofilm formation of Candida albicans. 3rd FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, 2-8 May 2009.
  18. Prasad, T., Hameed, S., Mukhopadhyay, C. K., Biswas, S., Setiadi, E. R., Ernst, J. F. & Prasad, R.  Morphogenic regulator Efg1p of Candida albicans affects drug susceptibilities independent of drug efflux pumps. 3rd FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, 2-8 May 2009.
  19. Monari, C., Bevilacqua, S., Piccioni, M., Pericolini, E., Perito, S., Calvitti, M., Bistoni, F., Kozel, T. R. & Vecchiarelli, A.  A microbial polysaccharide reduces the severity of rheumatoid arthritis via inhibition of Th17 differentiation.  Marie Curie Actions (MSCF-CT-2006-046108) TRiPR 2nd Conference, Innate Immunity and the Pathogenesis of Rheumatic Diseases.  May 6-8, 2009 Genoa, Italy.
  20. Nesseir, A., Chauvel, M., Diogo, D., Firon, A., Rossignol, T., Goyard, S., Kaffarnik, F.A.R., Selway, L., Peck S. C. & d’Enfert, C.  Understanding the role of the Candida albicans Yak1 kinase in the regulation hyphal growth.  Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  May 2-8, 2009.  La Colle-Sur-Loup, France.
  21. Wilson, D., Mayer, F. and Hube, B.  Identification of novel infection-associated genes by comparative genomics & transcriptional profiling.  Third FEBS Advanced Lecture Course Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence.  May 2-8, 2009.  La Colle sur Loup, France.
  22. Wilson, D., Mayer, F., and Hube, B.  The novel Candida albicans pathogenicity factors, AUG6, AUG8 and PGA16 are unique in vivo-expressed genes with specific roles in epithelial destruction.  Annual Meeting of the British Mycological Society.  September 1-4, 2009.  Dundee, UK.
  23. Sosinska, G. J., Sorgo, A., Heilmann, C. J., de Groot, P. W. J., de Koning, L., Dekker, H. L., de Koster, C., Brul, S. and Klis, F. M.  Comparative analysis of the Candida albicans cell wall proteome at neutral and acidic pH.  Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  May 2-8, 2009.  La Colle-Sur-Loup, France.
  24. Sosinska, G. J., Sorgo, A., Heilmann, C. J., de Groot, P. W. J., de Koning, L., Dekker, H. L., de Koster, C., Brul, S. and Klis, F. M.  Comparative analysis of the Candida albicans cell wall proteome at neutral and acidic pH.  Yeasterday 2009.  June 5, 2009.  Amsterdam, The Netherlands.
  25. Boisramé A., Cornu A., Da Costa G., Monniot C., Kos I. and Richard M.L. Dual role for the serine/threonine-rich domain in the Candida albicans Iff proteins family. Third FEBS Advanced Lecture Course on Human Fungal Pathogens.  La Colle-Sur-Loup, France, May 2-8, 2009
  26. Ene, I.V., Brown, A.J.P. Impact of non-fermentative growth on the C. albicans cell wall  and dynamic responses to osmotic stress. IMC9, Edinburgh UK, August 3, 2010
  27. Dobb, K.  Essential Genes as Broad Spectrum Antifungal Targets.  ASM 10th Candida and Candidiasis, Miami, USA, 22 – 26 March, 2010.
  28. Dobb, K.  The Sex Lives and Deadly Weapons of Killer Fungi.  Faculty of Life Sciences Symposium, University of Manchester, UK, 25 September 2010.
  29. Bohovych, I. M., Ene, I.V., Enjalbert, B., Odds, F.C., Gow, N.A.R. & Brown, A.J.P.  Glucose promotes stress resistance in the fungal pathogen, Candida albicans.  10th ASM Candida and Candidiasis Conference, Miami, FL, USA 22-26 March, 2010.
  30. Heilmann, C. J., Sorgo, A. G., Dekker, H. L., Brul, S., de Koster, C. G., de Koning, L. J., & Klis, F. M.  Quantitative mapping of the wall proteins of Candida albicans during the yeast-hypha transition ASM.  Candida and Candidiasis, Miami, USA, 22 – 26 March, 2010.
  31. Sorgo, A. G., Heilmann, C. J., Dekker, H. L., de Koster, C. G., Brul, S. & Klis, F. M.  Mass spectrometric analysis of the secretome of Candida albicans.  10th ASM Conference on Candida and Candidiasis, Miami, Florida, USA, 22-26 March, 2010.
  32. Cantero, P. D. & Ernst, J. F.  O-mannosylation and signalling pathways in Candida albicans.  10th ASM conference on Candida and Candidiasis, Miami, USA, 22-26 March 2010.
  33. Stichternoth, C., Setiadi, E., Vecchiarelli, A. & Ernst, J. F.  Sch9 kinase mediates CO2- and hypoxia-dependent repression of hyphal morphogenesis in Candida albicans.  10th ASM conference on Candida and Candidiasis, Miami, USA, 22-26 March 2010.
  34. Lassak, T. & Ernst, J. F.  Negative autoregulation of the EFG1 gene in Candida albicans. DGHM/VAAM joined conference, Hannover, Germany, 28-31 March 2010.
  35. Szafranski, E., Cottier, F. & Ernst, J.F.  Structure and function of the signaling mucin Msb2 in Candida albicans.  DGHM/VAAM joined conference, Hannover, Germany, 28-31 March 2010.
  36. Lütttich, A., Brunke, S., Jacobsen, I. & Hube, B.  Microevolution of a nonfilamentous Candida albicans mutant during co-incubation with macrophages.  DGHM – VAAM.  Hannover, Germany, 28 - 31March, 2010.
  37. Miramón, P., Heyken,A., Leonhardt, I., Barz, D. & Hube, B.  Interaction of Candida albicans with neutrophils: characterisation using mutants and GFP-reporter strains.  10th ASM Conference on Candida and Candidiasis.  Miami, Florida, 22 – 26 March, 2010.
  38. Wilson, D., Mayer, F. & Hube, B.  Candida albicans unique in vivo-expressed genes mediate host-pathogen interactions.  10th ASM Conference on Candida and Candidiasis.  Miami, Florida, 22 – 26 March, 2010.
  39. Bonhomme, J., Chauvel, M., Goyard, S., Rossignol, T., Roux, P., Garcia-sanchez, S., Aubert, S & d’Enfert, C. Tye7p, a positive regulator of glycolysis in the fungal pathogen Candida albicans is required for efficient biofilm formation. 10th ASM Candida and candiasis, Miami, USA, 22-26 March, 2010.
  40. Nesseir, M., Chauvel, D., Diogo, A., Firon, M., Legrand, T., Rossignol, S., Goyard. &  d’Enfert, C.  Characterization of the Candida albicans Yak1signalling network involved in the regulation of morphogenesis through structure function studies and a multi-copy suppressor screen. 10th ASM Candida and Candiasis.  Miami, USA.  22-26 March, 2010.
  41. Nesseir, M., Chauvel, T., Rossignol, S., Goyard, D., Diogo, A., Firon, L., Ma, C., Bouchier, & d’Enfert, C. An over-expression screen identifies novel regulators of morphogenesis in the fungal pathogen of humans Candida albicans.  2010 Yeast Genetics and Molecular Biology Meeting.  Vancouver, Canada, 27 July – 1 August, 2010.
  42. Bohovych I. Glucose promotes oxidative stress resistance in Candida albicans via specific signalling pathways. Stress responses – molecules, organisms and environments Meeting, London UK, 3-7 Jan 2011
  43. Bohovych I. Glucose promotes oxidative stress resistance in Candida albicans via specific signalling pathways 4th FEBS Advanced Lecture Course Human Fungal Pathogen 2011, La Colle sur Loup, France, May 07-13, 2011
  44. Bohovych I Glucose promotes oxidative stress resistance in Candida albicans via specific signalling pathways.  International Symposium “Non-Conventional Yeasts in the Postgenomic Era” Lviv, Ukraine, September 11-14 2011
  45. Ene, I.V., Brown, A.J.P. Growth on non-fermentative C sources affects cell wall architecture and hence dynamic responses to osmotic stress in the fungal pathogen C. Albicans. Joint BES / SEB / BS Symposium 2010 Stress Responses – molecules, organisms, environments. London, UK, 4-7 January 2011
  46. Ene, I.V., Neil A. R. Gow, Brown, A.J.P. Impact of non-fermentative growth on the C. albicans cell wall  and dynamic responses to osmotic stress. FEBS Advanced practical and lecture course. La Colle sur Loup, France, May 07-13, 2011
  47. S. Znaidi, V. Cabral, M. Legrand, A. Firon, M. Chauvel and C. d’Enfert. Fitness Profiling in Candida albicans by Systematic Gene Overexpression. . FEBS Advanced practical and lecture course. La Colle sur Loup, France, May 07-13, 2011
  48. Fraund, A., Stichternoth, C. and Ernst, J. F. Sch9 kinase integrates hypoxia and CO2 sensing to suppress hyphal morphogenesis in Candida albicans. 4th FEBS Advanced Lecture Course Human Fungal Pathogen 2011, La Colle sur Loup, France, May 07-13, 2011
  49. Kunigo, M., Ernst, J. F. and Tielker, D. Noursethricin-based expression vectors for the production of heterologous proteins in the yeast Candida utilis. VAAM-Tagung Karlsruhe, Germany, 3 June 2011
  50. Lassak, T., Lagadec, Q., Kurtz, D., Bussmann, M. and Ernst, J. F. 4rd FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, France, May 07-13, 2011
  51. Ullmann, S. and Ernst, J. F. Yil001/Orf19.7010, a novel protein involved in fungal O-glycosylation? 4th FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, France, May 07-13, 2011
  52. Leach MD, Tyc KM, Shapiro RS, Cowen LE, Klipp E, Brown AJP  Modelling the regulation of thermal adaptation by Hsf1 and Hsp90 in Candida albicans, a major fungal pathogen of humans. ECMTB 2011, Kraków (Poland) June 28 - July 2, 2011
  53. Tyc K, Leach MD, Brown AJP, Klipp E Systems biology approach to study heat shock response in C. Albicans. ICSB 2010, Edinburgh, UK, October 10 - 15, 2010
  55. Tyc KM, Kühn C, Klipp E. Analysis of host-pathogen interactions through agent based modeling approach. ICSB 2011, Heidelberg (Germany), August 28 - September 1, 2011
  56. Alice G. Sorgo, Clemens J. Heilmann, Henk L. Dekker, Stanley Brul, Chris de Koster, Leo J. de Koning and Frans M. Klis. The effects of fluconazole on the secretome, the wall proteome and wall integrity of the clinical fungus Candida albicans. 100th Anniversary Meeting of the NVvM, Papendal, Netherlands, April 18th-20th, 2011
  57. Alice G. Sorgo, Clemens J. Heilmann, Henk L. Dekker, Stanley Brul, Chris de Koster, Leo J. de Koning and Frans M. Klis. The effects of fluconazole on the secretome, the wall proteome and wall integrity of the clinical fungus Candida albicans. 4th FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, France, May 07-13, 2011
  58. Heilmann, C. Secrets of the Candida albicans secretome … revealed! 9th International Mycological Congress, Edinburgh, UK,  August 1st-6th 2010
  59. Heilmann C. Relative quantification of Candida albicans wall proteins reveals a strong correlation between hyphal induction methods. NWO Proteins, nucleic acids and Lipids, Veldhoven, Netherlands, December 6th-7th 2010
  60. Heilmann C., Relative quantification of wall protein dynamics reveals clues for vaccine development. Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011
  62. Heilmann C. Relative quantification of wall protein dynamics reveals clues for vaccine development. 4th FEBS Advanced Lecture Course "Human Fungal Pathogens", La Colle sur Loup, France, May 07-13, 2011
  63. Cheng SC, van de Veerdonk F, Smeekens S, Joosten LA, van der Meer JW, Kullberg BJ, Netea MG. Candida albicans Dampens Host Defense by Downregulating IL-17 Production. 10th ASM Candida and candidiasis. Miami, FL, USA, 22-26 March 2010
  64. Cheng SC, van de Veerdonk FL, Lenardon M, Stoffels M, Plantinga T, Smeekens S, Rizzetto L, Mukaremera L, Preechasuth K, Cavalieri D, Kanneganti TD, van der Meer JW, Kullberg BJ, Joosten LA, Gow NA, Netea MG The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011
  65. Diana C Rosentul, Theo S Plantinga, Omar JM Hamza, Leo AB Joosten,  Bart-Jan Kullberg, André JAM van der Ven, Evangelos J Giamarellos-Bourboulis, Mihai G Netea  GENETIC VARIABILITY IN GENES OF β-GLUCAN RECOGNITION PATHWAY AND SUSCEPTIBILITY TO OPPORTUNISTIC INFECTIONS IN HIV-POSITIVE PATIENTS 10th ASM Candida and candidiasis. Miami, FL, USA, 22-26 March 2010
  66. Diana C. Rosentul, Theo S. Plantinga, Marije Oosting, William K. Scott, Digna R. Velez Edwards, P. Brian Smith, Barbara D. Alexander, John C. Yang, Gregory M. Laird, Leo A.B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart-Jan Kullberg, Mihai G. Netea, Melissa D. Johnson GENETIC VARIATION IN THE Dectin-1/CARD9 RECOGNITION PATHWAY AND SUSCEPTIBILITY TO CANDIDEMIA. NCMLS PhD Retreat, Wageningen, The Netherlands, April 14-15 2011
  67. Diana C. Rosentul, Theo S. Plantinga, Marije Oosting, William K. Scott, Digna R. Velez Edwards, P. Brian Smith5, Barbara D. Alexander, John C. Yang, Gregory M. Laird5, Walter J. F. M. van der Velden, Bart Ferwerda, Annemiek B. van Spriel, Gosse Adema, Ton Feuth, J. Peter Donnelly, Gordon D. Brown, Nicole M. A. Blijlevens, Leo A.B. Joosten, Jos W. M. van der Meer, John R. Perfect, Bart-Jan Kullberg, Melissa D. Johnson, Mihai G. Netea. The Tyr238X dectin-1 polymorphism is a predisposing factor for mucosal Candida albicans infections but not candidemia. Gordon Research Conferences. Immunology of Fungal Infections. Galveston, Texas, USA, January 16-21, 2011

 

 

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